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Evidence-based GLP-1 & peptide discussion since 2023
TOOL · RECONSTITUTION & SYRINGE MATH · U-100 INSULIN SYRINGES
Enter what's in your vial, how much bacteriostatic water you add, and your target dose. The calculator returns the concentration, the draw in insulin units, and how many doses the vial holds.
⚕ Not medical advice. The GLP Lounge is a community forum. Nothing on this page is a substitute for guidance from a licensed clinician. Always involve your prescriber before starting, stopping, or changing a medication.
Concentration —
Draw —
Vial yields —
Dose exceeds one full U-100 syringe — add less water when reconstituting, or split the injection.
Draw to 10.0 units
Typical titration schedules
Label titrations for the approved injectables — your prescriber may go slower (slower is often better tolerated):
Step
Semaglutide (Wegovy)
Tirzepatide (Zepbound)
Weeks 1–4
0.25 mg weekly
2.5 mg weekly
Weeks 5–8
0.5 mg
5 mg
Weeks 9–12
1.0 mg
7.5 mg
Weeks 13–16
1.7 mg
10 mg
Maintenance
2.4 mg
10–15 mg
Reconstitution basics
Inject bacteriostatic water slowly down the vial wall; swirl gently, never shake.
More water = larger, easier-to-measure draws. Less water = smaller injection volume. The dose is identical.
Refrigerate reconstituted peptides (2–8 °C). Community practice treats 4–6 weeks as a sensible window for GLP-1 analogues — see stability threads in Compounding & Formulation.
One vial, one needle for drawing; never re-enter with a used injection needle.
Double-check every calculation against the math: units = dose (mg) ÷ concentration (mg/mL) × 100. If a number surprises you, post it in Dosing & Protocols before injecting.