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Forumsβ€ΊPublic Squareβ€ΊComparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide β€” anyone have experience?

Comparative pharmacokinetics: semaglutide vs tirzepatide vs retatrutide β€” anyone have experience?

Dr.AddMedPHL Mon, Dec 8, 2025 at 2:21 PM 5 replies 965 viewsPage 1 of 1
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Dr.AddMedPHL
Senior Member
1,234
6,234
Mar 2024
Philadelphia, PA
Dec 8, 2025 at 3:46 PM#1

πŸŽ‰ MILESTONE: Comparative pharmacokinetics semaglutide vs tirzepatide vs!

I can not believe I am typing this. When I started this journey I had zero hope.

Numbers: BMI went from 42 to 25.

Thank you to this community for keeping me sane through the hard parts. You know who you are. πŸ™

31 12FitDadDave, RunnerRach, TrialNerd_Beth and 28 others
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LibrarianMeg
Senior Member
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7,890
Mar 2024
Baltimore, MD
Dec 8, 2025 at 4:03 PM#2

Dr.AddMedPHL's experience with Comparative resonates deeply with mine. I went through almost the identical process β€” starting dose, titration timeline, side effects, everything.

The main difference: I started 3 months later. But the overall trajectory has been remarkably similar. Down 42 lbs in 7 months.

One thing I would add that Dr.AddMedPHL did not mention: the mental health improvements were just as significant.

31 2PharmD_Rodriguez, julia.endo, JessicaM_2024 and 28 others
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NurseKim_ATL
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Feb 2024
Atlanta, GA
Dec 8, 2025 at 4:20 PM#3

Thanks for sharing this, Dr.AddMedPHL. A few questions about your Comparative experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Comparative?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

43 21ingrid_STO, pete_nash, hank_denver and 40 others
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Dr.AddMedPHL
Senior Member
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6,234
Mar 2024
Philadelphia, PA
Dec 8, 2025 at 4:37 PM#4

OP here β€” wow, did not expect this much response! Thank you all for the thoughtful replies on Comparative.

To answer NurseKim_ATL: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion β€” this is exactly why I posted in a science-based community. πŸ™

Last edited: Dec 8, 2025 at 6:37 PM
42 24TomFromTexas, mike.trainer_LA, sarah_nash92 and 39 others
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stefan_berlin
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Oct 2024
Berlin, DE
Dec 8, 2025 at 4:54 PM#5

Relevant to Comparative pharmacokinetics β€” here is my latest bloodwork comparison:

Key improvements: A1C 7.2% β†’ 5.3%, triglycerides 215 β†’ 115 mg/dL, hsCRP 6.0 β†’ 0.9 mg/L. All on tirzepatide for 7 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

38 2TrialTracker_MD, JennaRN, LabKate and 35 others
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