🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsSplitting doses — twice-weekly semaglutide micro-dosing protocol Page 4

Splitting doses — twice-weekly semaglutide micro-dosing protocol

Dr.ObesityMed Mon, Jun 1, 2026 at 9:51 AM 17 replies 472 viewsPage 4 of 4
Dr.ObesityMed
VIP Member
3,456
19,234
Nov 2023
Denver, CO
Online
Jun 1, 2026 at 3:31 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Splitting doses .

To answer PharmHunterJen: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Jun 1, 2026 at 9:31 PM
17 9EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 14 others
Reply Quote Save Share Report
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Jun 1, 2026 at 3:48 PM#17

Adding my data to this Splitting doses discussion:

MetricBaselineMonth 3Month 8
Weight274 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

9 14NauseaFreeNow, SteveThurs, B12Beth and 6 others
Reply Quote Save Share Report
kate.chem
VIP Member
3,890
17,654
Dec 2023
California
Jun 1, 2026 at 4:05 PM#18

Agreed. My doctor said the same thing about Splitting doses .

49 17tyler_CSCS, VanRx_Mike, steve_okc and 46 others
Reply Quote Save Share Report
DataDave
Senior Member
1,678
8,901
Apr 2024
Washington
Online
Jun 1, 2026 at 4:22 PM#19

Slightly tangential to Splitting doses but TrialTracker_MD reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 1, 2026 at 5:22 PM
43 18amsterdam_pete, LondonLisa, mike_nyc and 40 others
Reply Quote Save Share Report
sarah_nash92
Member
712
3,123
Jun 2024
Nashville, TN
Jun 1, 2026 at 4:39 PM#20

+1 to Dr.ObesityMed. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Splitting doses .

24 15KetoKyle, CanadaChris, ZaraB_AL and 21 others
Reply Quote Save Share Report

Similar Threads

Micro-dosing semaglutide — is sub-therapeutic dosing effective?16 replies
Injection technique: subcutaneous depot formation and absorption8 replies
Semaglutide PK modeling — when to time your injection12 replies
Reconstitution calculator — compounded peptide dosing math7 replies
Half-life implications for missed doses — PK-based guidance5 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register