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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsPK/PD modeling for tirzepatide — anyone have experience? Page 2

PK/PD modeling for tirzepatide — anyone have experience?

CryptoCarl Sat, Jan 10, 2026 at 5:27 AM 24 replies 1,368 viewsPage 2 of 5
CryptoCarl
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Jan 10, 2026 at 8:17 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Jan 10, 2026 at 12:17 PM
44 23CryptoCarl, MariaRD, AussieAnna and 41 others
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RetaRick_CA
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Jan 10, 2026 at 8:34 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

15 6AmyNC_wife, SkepticalSean, Dr.CardioMD and 12 others
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Dr.ObesityLA
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Jan 10, 2026 at 8:51 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

36 17tampaLisa73, KarenAZ_mom, zoe_NC and 33 others
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