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Tagging this for the weekly digest. 👍
Slightly tangential to GLP-1R allosteric but Dr.PainCLE reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
KarenAZ_mom said:Follow-up question: how long did you wait before increasing your dose
This is exactly right. KarenAZ_mom articulated what I have been trying to explain to my doctor for months. The GLP-1R allosteric aspect is the most important factor.
Saving this for reference. Top-tier content.
Adding my data to this GLP-1R allosteric discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 262 lbs | 222 lbs | 207 lbs |
| A1C | 6.6% | 5.8% | 5.4% |
| hsCRP | 6.0 | 2.0 | 1.2 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.