Putting together a summary on my doctor says stay on 1mg since I keep seeing the same questions pop up.
I am not a medical professional (just a well-researched patient) so take this with appropriate salt, but I have compiled info from the clinical trials.
Happy to be corrected by the actual clinicians here — that is the whole point of posting it.
Dr.KarenChen's experience with My doctor says stay on resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 40 lbs in 5 months.
One thing I would add that Dr.KarenChen did not mention: the relationship with food fundamentally changed.
Thanks for sharing this, Dr.KarenChen. A few questions about your My doctor says stay experience:
I am in a similar boat and trying to learn from others' experiences before my next appointment.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on My doctor says stay on.
To answer Dr.DermMIA: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to My doctor says stay on 1mg but — here is my latest bloodwork comparison:
Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.