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ForumsDosing & ProtocolsSplitting doses — 12 month update Page 4

Splitting doses — 12 month update

steph_laguna Sat, Aug 16, 2025 at 5:30 AM 24 replies 1,702 viewsPage 4 of 5
paul_denver
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3,234
May 2024
Denver, CO
Aug 16, 2025 at 11:10 AM#16

Congrats SarahChen_PharmD!! You should be so proud of yourself. 🎉 👏

Last edited: Aug 16, 2025 at 5:10 PM
9 0Dr.LeslieOBGYN, MikeNYC_runner and 6 others
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kevin_tulsa
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2,123
Jun 2024
Tulsa, OK
Aug 16, 2025 at 11:27 AM#17

Saving this for reference. Quality thread.

14 12Dr.RheumBOS, greg_boulder, quinn_sf and 11 others
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wei_SG
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890
Nov 2024
Singapore, SG
Aug 16, 2025 at 11:44 AM#18

Slightly tangential to Splitting doses 12 month but MASHdoc_SA reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

21 4Dr.MetabolicMD, RetaRick_CA, JenPlateau and 18 others
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TirzTom
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Feb 2024
Florida
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Aug 16, 2025 at 12:01 PM#19

Relevant to Splitting doses 12 month — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 217 → 117 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

50 8SandraNC_45, Dr.EndoIndy, tom_AK and 47 others
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Dr.LeslieOBGYN
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2,567
May 2024
Dallas, TX
Aug 16, 2025 at 12:18 PM#20

Want to share my personal experience related to Splitting doses 12 month since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 288 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 18 months later: I am down 88 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Splitting doses 12 aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

23 22mike_mealprep, NicoleRaleigh, james_edin and 20 others
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