Mar 10, 2026 at 11:30 AM#11
LondonLisa — wow. This community is amazing.
22 2FranDenver, Dr.BariatricHTX, LindaRN_retired and 19 others
Reply Quote Save Share Report
Mar 10, 2026 at 11:47 AM#12
Slightly tangential to GLP-1 and gluconeogenesis but carlos_SATX reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
39 6KarenAZ_mom, zoe_NC, Dr.ObesityLA and 36 others
Reply Quote Save Share Report
Mar 10, 2026 at 12:04 PM#13
Thanks for sharing this, carlos_SATX. A few questions about your GLP-1 and gluconeoge experience:
- What dose worked best for you?
- How long before you noticed appetite suppression kicking in?
- Did your endo have any specific recommendations about GLP-1 and gluco?
I am in a similar boat and trying to learn from others' experiences before my next appointment.
Last edited: Mar 10, 2026 at 6:04 PM
1 0Dr.Martinez
Reply Quote Save Share Report
Mar 10, 2026 at 12:21 PM#14
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1 and gluconeogenesis.
To answer A1cHero_PHX: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
29 10LindaRN_retired, tommy_boulder, hyun_seoul and 26 others
Reply Quote Save Share Report
Mar 10, 2026 at 12:38 PM#15
Relevant to GLP-1 and gluconeogenesis my — here is my latest bloodwork comparison:
Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
12 24julia.endo, JessicaM_2024, TomFromTexas and 9 others
Reply Quote Save Share Report