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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — 12 month update Page 4

Incretin effect in healthy vs T2DM — 12 month update

marco_milano Mon, Oct 20, 2025 at 2:49 AM 28 replies 1,548 viewsPage 4 of 6
marco_milano
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Oct 20, 2025 at 8:29 AM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Incretin effect in.

To answer TomTeleRx: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Oct 20, 2025 at 12:29 PM
34 23kevin_tulsa, Dr.PainCLE, mike_mealprep and 31 others
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Dr.RaviCardio
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Oct 20, 2025 at 8:46 AM#17

Adding my data to this Incretin effect in discussion:

MetricBaselineMonth 3Month 6
Weight272 lbs227 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Oct 20, 2025 at 9:46 AM
16 23anna.melb_AU, mark_tokyo, hans_munich and 13 others
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JennaRN
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Oct 20, 2025 at 9:03 AM#18

Exactly this. My pharmacist said the same thing about Incretin effect in.

Last edited: Oct 20, 2025 at 10:03 AM
18 7BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 15 others
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Dr.AddMedPHL
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Philadelphia, PA
Oct 20, 2025 at 9:20 AM#19

Slightly tangential to Incretin effect in but KevinCompounds reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

36 18TomFromTexas, mike.trainer_LA, sarah_nash92 and 33 others
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julia.endo
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Cincinnati, OH
Oct 20, 2025 at 9:37 AM#20

+1 to marco_milano. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Incretin effect in.

30 2chris_chi24, tampaLisa73, KarenAZ_mom and 27 others
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