πŸͺ The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊMetabolic Health & Diabetesβ€ΊGLP-1 and gluconeogenesis β€” what worked for you?

GLP-1 and gluconeogenesis β€” what worked for you?

matt_MKE Mon, Oct 20, 2025 at 10:35 AM 50 replies 1,666 viewsPage 1 of 10
This thread is more than 7 months old. Information may be outdated. Consider searching for more recent discussions.
matt_MKE
Member
312
1,345
Sep 2024
Milwaukee, WI
Oct 20, 2025 at 12:00 PM#1

πŸŽ‰ MILESTONE: GLP-1 and gluconeogenesis what worked for!

I can not believe I am typing this. 6 months ago I never thought I would be here.

Numbers: Started at 245 lbs, currently at 200 lbs.

Thank you to this community for keeping me sane through the hard parts. You know who you are. πŸ™

46 22andrew_nyc, Dr.EndoEP, GraceAZ_72 and 43 others
Reply Quote Save Share Report
SarahChen_PharmD
VIP Member
4,567
22,341
Dec 2023
San Diego, CA
Oct 20, 2025 at 12:17 PM#2

To answer the question about GLP-1 and gluconeogenesis what worked for you? β€” in my experience this comes down to a few key factors.

I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on GLP-1 and gluconeogenesis seems solid.

What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest matt_MKE try the same approach and reporting back.

1 8NurseKim_ATL
Reply Quote Save Share Report
LipidDoc_ATL
Senior Member
1,123
5,678
Apr 2024
Atlanta, GA
Oct 20, 2025 at 12:34 PM#3

SarahChen_PharmD nailed it. Building on that β€” GLP-1 and gluconeogenesis what is something I discuss with my dietitian regularly, and their clinical perspective aligns with what SarahChen_PharmD described.

One thing I would add: discussing this with your provider early helps.

1 19AttorneyGrant
Reply Quote Save Share Report
SteveThurs
Member
523
2,345
Sep 2024
Wisconsin
Online
Oct 20, 2025 at 12:51 PM#4

Subscribing to this thread. GLP-1 and gluconeogenesis is exactly what I've been researching. πŸ™

Last edited: Oct 20, 2025 at 4:51 PM
4 15DoseLogDan, SleepFixSam, PurityPaulOR and 1 other
Reply Quote Save Share Report
Dr.PulmRoch
Member
456
2,345
Jun 2024
Rochester, MN
Oct 20, 2025 at 1:08 PM#5

Clinical perspective on GLP-1 and gluconeogenesis what worked:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows β€” and what I see in practice β€” is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

Last edited: Oct 20, 2025 at 2:08 PM
1 14KristenIndy
Reply Quote Save Share Report
123…10

Similar Threads

SUSTAIN-6 to SELECT β€” the cardiovascular evidence timeline14 replies
GLP-1 and insulin resistance β€” HOMA-IR improvement data17 replies
Metabolic syndrome reversal criteria β€” how GLP-1 addresses all 55 replies
A1C target achievement rates β€” sema vs tirz comparison8 replies
SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design3 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register