Jun 4, 2025 at 8:21 PM#16
Congrats Dr.SurgeonPGH!! You should be so proud of yourself. 🎉 👏
Last edited: Jun 4, 2025 at 9:21 PM
42 15hyun_seoul, jim_asheville, matt_MKE and 39 others
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Jun 4, 2025 at 8:38 PM#17
Slightly tangential to cAMP signaling cascade but newstart_MO reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
6 16james_edin, FranDenver, Dr.BariatricHTX and 3 others
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Jun 4, 2025 at 8:55 PM#18
Adding my data to this cAMP signaling cascade discussion:
| Metric | Baseline | Month 5 | Month 6 |
|---|---|---|---|
| Weight | 244 lbs | 244 lbs | 209 lbs |
| A1C | 6.8% | 6.0% | 5.2% |
| hsCRP | 8.0 | 4.0 | 1.0 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.
38 12SkepticalSean, Dr.CardioMD, EndoResFellow and 35 others
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Jun 4, 2025 at 9:12 PM#19
Reading this thread on cAMP signaling cascade hits close to home. Night shift nurse — I started at 295 lbs and felt like I would tried everything.
11 months on tirz and I am a different person. Not just the 70 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about cAMP signaling — take the leap. It was the best health decision I have ever made. ❤️
41 21FitDadDave, RunnerRach, TrialNerd_Beth and 38 others
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Jun 4, 2025 at 9:29 PM#20
Dr.EndoEP — that is really helpful context on cAMP signaling cascade. Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
9 12julia.endo, JessicaM_2024, TomFromTexas and 6 others
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