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ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — binding affinity comparison Page 3

Small molecule vs peptide GLP-1 agonists — binding affinity comparison

PeptideChemSF Sun, May 31, 2026 at 5:43 PM 16 replies 583 viewsPage 3 of 4
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May 31, 2026 at 9:58 PM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

23 21PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 20 others
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RetaRick_CA
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May 31, 2026 at 10:15 PM#12

Slightly tangential to Small molecule vs peptide but Dr.ReproEndo reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

42 2AmyNC_wife, SkepticalSean, Dr.CardioMD and 39 others
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roxy_nash
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May 31, 2026 at 10:32 PM#13
KristenIndy said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. KristenIndy articulated what I have been trying to explain to my friends for months. The Small molecule vs peptide aspect is what made the difference for me.

Last edited: Jun 1, 2026 at 4:32 AM
38 14tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 35 others
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SaraMom3
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May 31, 2026 at 10:49 PM#14

Saving this for reference. Quality thread.

Last edited: Jun 1, 2026 at 2:49 AM
47 21CanadaChris, ZaraB_AL, JakeSmashed95 and 44 others
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Dr.RaviCardio
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May 31, 2026 at 11:06 PM#15

Adding my data to this Small molecule vs peptide discussion:

MetricBaselineMonth 3Month 6
Weight248 lbs218 lbs213 lbs
A1C7.2%5.8%5.2%
hsCRP7.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

21 21jason_sac26, chris_chi24, tampaLisa73 and 18 others
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