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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsSo the drug literally changes your brain?? That is wild — anyone have experience? Page 4

So the drug literally changes your brain?? That is wild — anyone have experience?

Dr.PulmRoch Fri, Jan 31, 2025 at 1:55 PM 49 replies 2,218 viewsPage 4 of 10
Dr.PulmRoch
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Jan 31, 2025 at 7:35 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on So the drug literally.

To answer sean_dublin: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

48 3rachel_ABQ, traveltech_sara, AttorneyGrant and 45 others
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dan_philly
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Jul 2024
Philadelphia, PA
Jan 31, 2025 at 7:52 PM#17

Adding my data to this So the drug literally discussion:

MetricBaselineMonth 3Month 8
Weight262 lbs237 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

5 18AmyNC_wife, SkepticalSean, Dr.CardioMD and 2 others
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adam_van
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Nov 2024
Vancouver, CA
Jan 31, 2025 at 8:09 PM#18

Agreed. My doctor said the same thing about So the drug.

13 14LindaRN_retired, tommy_boulder, hyun_seoul and 10 others
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VendorMark
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Jan 2024
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Jan 31, 2025 at 8:26 PM#19

Slightly tangential to So the drug literally but Dr.SurgeonPGH reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

15 20Dr.PeteFamMed, claudia_zurich, nancy_portland and 12 others
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marcus_mpls
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Nov 2024
Minneapolis, MN
Jan 31, 2025 at 8:43 PM#20

+1 to Dr.PulmRoch. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with So the drug literally.

5 10mona_PHX, andrew_nyc, Dr.EndoEP and 2 others
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