pam_columbus's experience with Biased agonism at GLP-1R resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.
The main difference: I had more GI issues initially. But the overall trajectory has been remarkably similar. Down 53 lbs in 8 months.
One thing I would add that pam_columbus did not mention: insurance coverage was a major hurdle.
Clinical perspective on Biased agonism at GLP-1R 12 month:
I have managed over 200 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.
Subscribing to this thread. Biased agonism at GLP-1R is exactly what I've been researching. 🙏