🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsStructure-function of tirzepatide — 12 month update Page 4

Structure-function of tirzepatide — 12 month update

RunnerRach Thu, May 30, 2024 at 1:05 AM 50 replies 2,566 viewsPage 4 of 10
RunnerRach
Member
467
2,123
Aug 2024
Boston, MA
May 30, 2024 at 6:45 AM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Structure-function of.

To answer DoseLogDan: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

37 16BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 34 others
Reply Quote Save Share Report
dave_SLC
Member
345
1,567
Aug 2024
Salt Lake City, UT
May 30, 2024 at 7:02 AM#17

Relevant to Structure-function of — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

22 17NicoleRaleigh, james_edin, FranDenver and 19 others
Reply Quote Save Share Report
DataDave
Senior Member
1,678
8,901
Apr 2024
Washington
Online
May 30, 2024 at 7:19 AM#18

100%. My provider said the same thing about Structure-function.

39 21LondonLisa, mike_nyc, VendorMark and 36 others
Reply Quote Save Share Report
Dr.SportsMedIN
Senior Member
1,456
6,789
Feb 2024
Indianapolis, IN
May 30, 2024 at 7:36 AM#19

Slightly tangential to Structure-function of but JennaRN reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

31 0Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 28 others
Reply Quote Save Share Report
mike.trainer_LA
Senior Member
1,567
7,234
Apr 2024
Los Angeles, CA
May 30, 2024 at 7:53 AM#20
RunnerRach said:
Thank you all for the thoughtful replies on Structure-function of

This is exactly right. RunnerRach articulated what I have been trying to explain to my doctor for months. The Structure-function of aspect is the most important factor.

13 0marcus_mpls, DeniseRN_TPA, SandraNC_45 and 10 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register