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ForumsPharmacology & MechanismsWhy does it stop working after a while for some people — what worked for you? Page 3

Why does it stop working after a while for some people — what worked for you?

Dr.ObesityLA Thu, May 2, 2024 at 3:42 PM 19 replies 2,021 viewsPage 3 of 4
mike_mealprep
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Chicago, IL
May 2, 2024 at 7:57 PM#11

steve_okc — wow. This community is amazing.

17 0mia_MS2, LeilaHI, marcus_mpls and 14 others
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Dr.NutriCornell
Senior Member
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Mar 2024
Ithaca, NY
May 2, 2024 at 8:14 PM#12

Slightly tangential to Why does it stop working but Dr.ObesityLA reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: May 2, 2024 at 10:14 PM
15 0Dr.SleepRoch, laura_annarbor, JenMemphis and 12 others
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Dr.NephBHM_UK
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Jun 2024
Birmingham, UK
May 2, 2024 at 8:31 PM#13

Thanks for sharing this, Dr.ObesityLA. A few questions about your Why does it stop experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Why does it?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

24 20PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 21 others
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Dr.ObesityLA
VIP Member
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Los Angeles, CA
May 2, 2024 at 8:48 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Why does it stop working.

To answer Dr.NutriCornell: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

12 14chris_chi24, tampaLisa73, KarenAZ_mom and 9 others
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Dr.PeteFamMed
Senior Member
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Jan 2024
Minneapolis, MN
May 2, 2024 at 9:05 PM#15

Relevant to Why does it stop working after — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

43 10FranDenver, Dr.BariatricHTX, LindaRN_retired and 40 others
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