🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOral semaglutide bioavailability optimization — what worked for you? Page 3

Oral semaglutide bioavailability optimization — what worked for you?

mia_MS2 Sat, Oct 4, 2025 at 9:10 PM 12 replies 1,158 viewsPage 3 of 3
quinn_sf
Member
489
2,123
Jun 2024
San Francisco, CA
Oct 5, 2025 at 1:25 AM#11

adam_van — wow. This community is amazing.

12 0tane_welly, Dr.PathRoch, mona_PHX and 9 others
Reply Quote Save Share Report
Dr.NateNeph
VIP Member
2,987
16,234
Dec 2023
Houston, TX
Oct 5, 2025 at 1:42 AM#12

Slightly tangential to Oral semaglutide but mia_MS2 reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Oct 5, 2025 at 3:42 AM
17 2NauseaFreeNow, SteveThurs, B12Beth and 14 others
Reply Quote Save Share Report
RickReta_CO
Member
312
1,234
Jan 2025
Colorado
Oct 5, 2025 at 1:59 AM#13

Thanks for sharing this, mia_MS2. A few questions about your Oral semaglutide experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Oral semaglutid?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Oct 5, 2025 at 6:59 AM
47 8hyun_seoul, jim_asheville, matt_MKE and 44 others
Reply Quote Save Share Report
mia_MS2
New Member
8
23
Jun 2026
Ann Arbor, MI
Oct 5, 2025 at 2:16 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Oral semaglutide.

To answer Dr.NateNeph: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

7 23steve_okc, dave_SLC, FDA_TrackerJim and 4 others
Reply Quote Save Share Report
stefan_berlin
Member
234
1,123
Oct 2024
Berlin, DE
Oct 5, 2025 at 2:33 AM#15

Relevant to Oral semaglutide — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 213 → 113 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

8 11TrialTracker_MD, JennaRN, LabKate and 5 others
Reply Quote Save Share Report

Similar Threads

Orforglipron Phase 3 ATTAIN-1 topline — oral non-peptide GLP-116 replies
Oral semaglutide 50mg (Rybelsus HD) — OASIS program results12 replies
Danuglipron BID dosing — Pfizer oral GLP-1 update7 replies
Oral vs injectable GLP-1: bioavailability and efficacy comparison5 replies
Orforglipron food interaction profile — no fasting requirement15 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register