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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHas anyone dealt with oral glp-1 adherence? Page 5

Has anyone dealt with oral glp-1 adherence?

sarah.morrison Wed, Sep 10, 2025 at 6:42 PM 33 replies 1,760 viewsPage 5 of 7
MaxMetOK
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Sep 11, 2025 at 1:47 AM#21

JakeBK_lifts — that is really helpful context on Has anyone dealt with. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

4 3PharmHunterJen, TomTeleRx, DoseLogDan and 1 other
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Dr.ObesityLA
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Sep 11, 2025 at 2:04 AM#22

To answer JenPlateau's question specifically:

From a clinical standpoint, Has anyone dealt with oral is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

17 5KarenAZ_mom, zoe_NC, Dr.ObesityLA and 14 others
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emma_london
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Sep 11, 2025 at 2:21 AM#23

Thank you MaxMetOK! This is incredibly helpful. Taking this to my next appointment. 🙏

7 5TomFromTexas, mike.trainer_LA, sarah_nash92 and 4 others
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lucas_SP_BR
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Sep 11, 2025 at 2:38 AM#24

Relevant to Has anyone dealt with oral — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 219 → 119 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

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carl_compliance
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Sep 11, 2025 at 2:55 AM#25

Slightly tangential to Has anyone dealt with but MaxMetOK reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

24 6dave_SLC, FDA_TrackerJim, ricardo_MIA and 21 others
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