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ForumsOral GLP-1 AgonistsATTAIN-2: orforglipron in T2DM — 12 month update Page 3

ATTAIN-2: orforglipron in T2DM — 12 month update

RetaRick_CA Sat, Aug 16, 2025 at 1:22 PM 35 replies 1,535 viewsPage 3 of 7
NauseaFreeNow
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Indiana
Aug 16, 2025 at 5:37 PM#11

+1 to LibrarianMeg. Especially the point about "Re: ATTAIN-2 orforglipron in T2DM — the..." — I have seen the same in my own experience with ATTAIN-2 orforglipron in.

45 15stefan_berlin, Dr.EM_Chicago, pete_RVA and 42 others
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PeptideSynthNJ
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Aug 2024
Princeton, NJ
Aug 16, 2025 at 5:54 PM#12

Want to share my personal experience related to ATTAIN-2 orforglipron in T2DM since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 276 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 71 lbs, my labs have normalized, and I am off 2 of my 3 medications. The ATTAIN-2 orforglipro aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

10 8NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 7 others
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TomTeleRx
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Feb 2025
Delaware
Aug 16, 2025 at 6:11 PM#13

TrialTracker_MD — that is really helpful context on ATTAIN-2 orforglipron in. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

45 1LibrarianMeg, bri_stats, pete_manc_UK and 42 others
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hyun_seoul
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Jul 2024
Seoul, KR
Aug 16, 2025 at 6:28 PM#14

To answer PeptideSynthNJ's question specifically:

From a clinical standpoint, ATTAIN-2 orforglipron in T2DM is something I discuss with patients regularly.

The short answer: discuss this specific situation with your prescribing provider.

The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.

29 23BariatricNurseD, MASHdoc_SA, GenomicsKate and 26 others
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Dr.EM_Chicago
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May 2024
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Aug 16, 2025 at 6:45 PM#15

Saving this for reference. Quality thread.

Last edited: Aug 16, 2025 at 10:45 PM
4 15lisa_labSD, adam_van, Dr.SurgeonPGH and 1 other
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