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Tagging this for the weekly digest. 👍
Slightly tangential to Tirzepatide dual agonism but JennaRN reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
pat_auckland said:Follow-up question: how long did you wait before increasing your dose
This is exactly right. pat_auckland articulated what I have been trying to explain to my doctor for months. The Tirzepatide dual agonism aspect is the most important factor.
Saving this for reference. Top-tier content.
Adding my data to this Tirzepatide dual agonism discussion:
| Metric | Baseline | Month 4 | Month 8 |
|---|---|---|---|
| Weight | 254 lbs | 239 lbs | 199 lbs |
| A1C | 6.8% | 6.2% | 5.4% |
| hsCRP | 8.0 | 3.0 | 1.2 |
Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.