Slightly tangential to Orforglipron Phase 2 but JenPlateau reminded me — what is the latest on the oral formulations?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Thanks for sharing this, JenPlateau. A few questions about your Orforglipron Phase 2 experience:
- What dose did you start at?
- How long before you noticed side effects improving?
- Did your provider have any specific recommendations about Orforglipron?
I am in a similar boat and trying to learn from others' experiences before my next appointment.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Orforglipron Phase 2.
To answer RegAffairsDC: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to Orforglipron Phase 2 weight — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 193 → 93 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.