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Tagging this for the weekly digest. 👍
Slightly tangential to Tirzepatide half-life and but julia.endo reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
mia_MS2 said:Follow-up question: how long did you wait before increasing your dose
This is exactly right. mia_MS2 articulated what I have been trying to explain to my doctor for months. The Tirzepatide half-life and aspect is the most important factor.
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Adding my data to this Tirzepatide half-life and discussion:
| Metric | Baseline | Month 5 | Month 8 |
|---|---|---|---|
| Weight | 254 lbs | 239 lbs | 209 lbs |
| A1C | 6.8% | 6.0% | 5.4% |
| hsCRP | 8.0 | 4.0 | 1.2 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.