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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — 6 month update Page 5

Muscle protein synthesis rates on GLP-1 — 6 month update

PedsEndoPhilly Wed, Sep 10, 2025 at 9:45 PM 31 replies 1,627 viewsPage 5 of 7
raj_cambridge
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Cambridge, MA
Sep 11, 2025 at 4:50 AM#21

Slightly tangential to Muscle protein synthesis but sarah.morrison reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Sep 11, 2025 at 5:50 AM
12 2SleepFixSam, PurityPaulOR, MaxMetOK and 9 others
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JessicaH_TX
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Dec 2023
Houston, TX
Sep 11, 2025 at 5:07 AM#22

Bookmarked 📌 The Muscle protein info in this thread is essential. Coming back to this for sure.

Last edited: Sep 11, 2025 at 9:07 AM
26 13sarah_TO, wendy_avl, jason_paloalto and 23 others
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B12Beth
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Oct 2024
Maryland
Sep 11, 2025 at 5:24 AM#23

Slightly tangential to Muscle protein synthesis but stefan_berlin reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

42 22DanielChem_CHI, marco_milano, pam_columbus and 39 others
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BiostatsBrad
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Jul 2024
Durham, NC
Sep 11, 2025 at 5:41 AM#24

Adding my data to this Muscle protein synthesis discussion:

MetricBaselineMonth 4Month 8
Weight242 lbs247 lbs217 lbs
A1C6.6%6.2%5.4%
hsCRP6.03.00.8

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Sep 11, 2025 at 6:41 AM
44 1james_edin, FranDenver, Dr.BariatricHTX and 41 others
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BenResearch_OR
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Dec 2023
Oregon
Sep 11, 2025 at 5:58 AM#25

Reading this thread on Muscle protein synthesis hits close to home. Dad of 2 checking in — I started at 293 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 68 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Muscle protein — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Sep 11, 2025 at 6:58 AM
12 23PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 9 others
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