Apr 30, 2026 at 10:15 AM#11
Thank you amsterdam_pete! This is incredibly helpful. Taking this to my next appointment. 🙏
21 5Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 18 others
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Apr 30, 2026 at 10:32 AM#12
Slightly tangential to Has anyone dealt with but Dr.SurgeonPGH reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Last edited: Apr 30, 2026 at 4:32 PM
26 18alex_tucson, kevin_tulsa, Dr.PainCLE and 23 others
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Apr 30, 2026 at 10:49 AM#13
Thanks for sharing this, Dr.SurgeonPGH. A few questions about your Has anyone dealt experience:
- What dose did you start at?
- How long before you noticed side effects improving?
- Did your provider have any specific recommendations about Has anyone deal?
I am in a similar boat and trying to learn from others' experiences before my next appointment.
37 20stefan_berlin, Dr.EM_Chicago, pete_RVA and 34 others
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Apr 30, 2026 at 11:06 AM#14
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with.
To answer hans_munich: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
35 18RickReta_CO, PharmHunterJen, TomTeleRx and 32 others
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Apr 30, 2026 at 11:23 AM#15
Adding my data to this Has anyone dealt with discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 246 lbs | 216 lbs | 201 lbs |
| A1C | 7.0% | 5.8% | 5.4% |
| hsCRP | 5.0 | 2.0 | 1.2 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.
21 1pete_manc_UK, anna.melb_AU, mark_tokyo and 18 others
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