SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 265 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 55 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

BiostatsBrad — that is really helpful context on SURMOUNT-5 Tirzepatide vs. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 282 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 62 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

maria_elpaso — that is really helpful context on SURMOUNT-5 Tirzepatide vs. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to SURMOUNT-5 Tirzepatide vs since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 254 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 69 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SURMOUNT-5 Tirzepati aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.