Dr.RaviCardio — that is really helpful context on ClinicalTrials.gov GLP-1. Follow-up question: did you change anything about your diet at the same time?
I am in a similar situation (month 2) and trying to set realistic expectations.
To answer TrialTracker_MD's question specifically:
From a clinical standpoint, ClinicalTrials.gov GLP-1 trial is well-supported by the literature.
The short answer: follow the standard titration protocol and reassess at 4-6 weeks.
The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.
rachel_ABQ — wow. This community is amazing.
Adding my data to this ClinicalTrials.gov GLP-1 discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 242 lbs | 232 lbs | 207 lbs |
| A1C | 6.6% | 5.8% | 5.4% |
| hsCRP | 6.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.
Slightly tangential to ClinicalTrials.gov GLP-1 but rachel_ABQ reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.