GLP-1 receptor desensitization and tachyphylaxis — looking for input — Page 2 — Public Square

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May 6, 2025 at 5:45 PM#6

Dr.SurgeonPGH said:
I have been dealing with this for several months now, and what I have found is that individual respo

Gonna push back on this one. GLP-1 receptor desensitization and is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: May 6, 2025 at 8:45 PM

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jason_paloalto

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May 6, 2025 at 6:02 PM#7

Adding my data to this GLP-1 receptor discussion:

Metric	Baseline	Month 5	Month 8
Weight	246 lbs	236 lbs	221 lbs
A1C	7.0%	6.0%	5.4%
hsCRP	5.0	4.0	1.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

Last edited: May 6, 2025 at 11:02 PM

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stefan_berlin

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May 6, 2025 at 6:19 PM#8

pat_auckland — wow. I've been looking for this exact info for weeks.

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chris_chi24

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May 6, 2025 at 6:36 PM#9

Slightly tangential to GLP-1 receptor but SandraNC_45 reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: May 6, 2025 at 9:36 PM

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