Amylin co-agonism: CagriSema REDEFINE results and implications — 6 month update

Congrats JessicaH_TX!! You should be so proud of yourself. 🎉 👏

sarah_TO — that is really helpful context on Amylin co-agonism. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to Amylin co-agonism CagriSema since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 253 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 83 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Amylin co-agonism aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

sarah_TO — that is really helpful context on Amylin co-agonism. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to Amylin co-agonism CagriSema since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 270 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 35 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Amylin co-agonism aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.