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ForumsCardiovascular OutcomesShould I be worried about my heart rate going up? — what worked for you?

Should I be worried about my heart rate going up? — what worked for you?

BiostatsBrad Wed, Jan 28, 2026 at 7:18 AM 8 replies 854 viewsPage 1 of 2
BiostatsBrad
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Jan 28, 2026 at 8:43 AM#1

Should I be worried about my heart rate going up? — what worked for you?

Saw this come across my feed today and thought the community would want to discuss.

Should I be worried about my is something that affects a lot of us here, and the latest information is worth paying attention to. I'll share what I know and hopefully others can fill in the gaps.

Key points as I understand them:

  • This has been evolving over the past few months
  • There are different perspectives on how to approach it
  • The practical implications depend on your specific situation

What are you all hearing from your providers about this? Anyone have direct experience to share?

3 8LindaRN_retired, tommy_boulder, hyun_seoul
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DataDave
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Jan 28, 2026 at 9:00 AM#2

BiostatsBrad's experience with Should I be worried about resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 40 lbs in 5 months.

One thing I would add that BiostatsBrad did not mention: the relationship with food fundamentally changed.

Last edited: Jan 28, 2026 at 10:00 AM
2 15mike_nyc, VendorMark
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TirzTom
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Jan 28, 2026 at 9:17 AM#3

Thanks for sharing this, BiostatsBrad. A few questions about your Should I be worried experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Should I be?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Jan 28, 2026 at 1:17 PM
16 10Dr.EndoIndy, tom_AK, josh_phd_bmore and 13 others
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BiostatsBrad
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Jan 28, 2026 at 9:34 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Should I be worried about.

To answer TirzTom: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

21 20james_edin, FranDenver, Dr.BariatricHTX and 18 others
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dave_SLC
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Jan 28, 2026 at 9:51 AM#5

Relevant to Should I be worried about my — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

41 14Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 38 others
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