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Tagging this for the weekly digest. 👍
Slightly tangential to SELECT trial 20% MACE but TrialNerd_Beth reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
kevin_tulsa said:Follow-up question: how long did you wait before increasing your dose
This is exactly right. kevin_tulsa articulated what I have been trying to explain to my doctor for months. The SELECT trial 20% MACE aspect is the most important factor.
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Adding my data to this SELECT trial 20% MACE discussion:
| Metric | Baseline | Month 4 | Month 8 |
|---|---|---|---|
| Weight | 246 lbs | 246 lbs | 211 lbs |
| A1C | 7.0% | 6.2% | 5.4% |
| hsCRP | 5.0 | 3.0 | 1.2 |
Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.