Cortisol and GLP-1 — HPA axis during caloric deficit

Just wanted to say — for anyone reading this Cortisol and GLP-1 thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

As a pharmacist, I want to add some clinical context to this discussion on Cortisol and GLP-1 HPA axis during.

Building on what tammy_FL said — the evidence base here is robust. The key publications to reference are from the FLOW program[1].

Key clinical points:

1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
2. Side effect profile is predictable and usually manageable with standard protocols
3. Monitoring should include baseline labs and follow-up at 3-month intervals
4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

pam_columbus said:

The first few weeks are the hardest

Gonna push back on this one. Cortisol and GLP-1 HPA axis during is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

Yep. My endo said the same thing about Cortisol and GLP-1 .

Reading this thread on Cortisol and GLP-1 HPA hits close to home. Night shift nurse — I started at 287 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 62 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Cortisol and GLP-1 — take the leap. It was the best health decision I have ever made. ❤️