SOUL trial preliminary data — November 2025

Want to share my personal experience related to SOUL trial preliminary data since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 268 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 10 months later: I am down 48 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SOUL trial prelimina aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

Relevant to SOUL trial preliminary data — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Want to share my personal experience related to SOUL trial preliminary data since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 285 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 16 months later: I am down 55 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SOUL trial prelimina aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

TirzTom — that is really helpful context on SOUL trial preliminary. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to SOUL trial preliminary data since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 257 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 8 months later: I am down 62 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SOUL trial prelimina aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.