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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide and muscle preservation? Page 2

Has anyone dealt with tirzepatide and muscle preservation?

marcus_mpls Thu, Oct 31, 2024 at 4:36 AM 50 replies 2,916 viewsPage 2 of 10
PharmacoVig_BOS
Senior Member
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Feb 2024
Boston, MA
Oct 31, 2024 at 7:26 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Oct 31, 2024 at 10:26 AM
2 4amsterdam_pete, LondonLisa
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steve_okc
Member
489
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Jul 2024
Oklahoma City, OK
Oct 31, 2024 at 7:43 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

42 5JakeSmashed95, NauseaFreeNow, SteveThurs and 39 others
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wei_SG
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890
Nov 2024
Singapore, SG
Oct 31, 2024 at 8:00 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

1 21Dr.MetabolicMD
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