Putting together a summary on will reta make sema and tirz since I keep seeing the same questions pop up.
I am not a medical professional (just a well-researched patient) so take this with appropriate salt, but I have compiled info from the clinical trials.
Happy to be corrected by the actual clinicians here — that is the whole point of posting it.
To answer the question about Will reta make sema and tirz obsolete? — in my experience this comes down to a few key factors.
I have been dealing with this for about 6 months now, and what I have found is that individual responses really do vary. That said, the general consensus on Will reta make sema and tirz seems solid.
What specifically worked for me: starting with a lower dose and titrating slowly. I would suggest andrew_nyc try the same approach and reporting back.
SarahChen_PharmD nailed it. Building on that — Will reta make sema and tirz is something I discuss with my dietitian regularly, and their clinical perspective aligns with what SarahChen_PharmD described.
One thing I would add: discussing this with your provider early helps.
Clinical perspective on Will reta make sema and tirz obsolete?:
I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.