OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on NNT for MACE prevention .
To answer andrew_nyc: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Adding my data to this NNT for MACE prevention discussion:
| Metric | Baseline | Month 5 | Month 8 |
|---|---|---|---|
| Weight | 258 lbs | 233 lbs | 203 lbs |
| A1C | 7.2% | 6.0% | 5.4% |
| hsCRP | 7.0 | 4.0 | 0.8 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.
Can confirm — identical experience.
Slightly tangential to NNT for MACE prevention but Dr.PeteFamMed reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
+1 to Dr.LipidDallas. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with NNT for MACE prevention .