SHBG changes during weight loss on GLP-1 — my results so far

Want to share my personal experience related to SHBG changes during weight since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 286 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 51 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SHBG changes during aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

jason_paloalto — that is really helpful context on SHBG changes during. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Want to share my personal experience related to SHBG changes during weight since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 258 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 6 months later: I am down 58 lbs, my labs have normalized, and I am off 2 of my 3 medications. The SHBG changes during aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

jason_paloalto — that is really helpful context on SHBG changes during. Follow-up question: did you experience any side effects during this phase?

I am in a similar situation (about to start) and trying to set realistic expectations.

Want to share my personal experience related to SHBG changes during weight since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 275 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 65 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The SHBG changes during aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.