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ForumsRetatrutide & Triple AgonistsRetatrutide and fatty liver — 6 month update Page 3

Retatrutide and fatty liver — 6 month update

Dr.GastroMayo Tue, Dec 9, 2025 at 11:45 AM 13 replies 1,017 viewsPage 3 of 3
KarenAZ_mom
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Scottsdale, AZ
Dec 9, 2025 at 4:00 PM#11

traveltech_sara — wow. I've been looking for this exact info for weeks.

2 10anna.melb_AU, mark_tokyo
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PharmHunterJen
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Jul 2024
Illinois
Dec 9, 2025 at 4:17 PM#12

Slightly tangential to Retatrutide and fatty but Dr.GastroMayo reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

44 16alex_tucson, kevin_tulsa, Dr.PainCLE and 41 others
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AmyNC_wife
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Jun 2024
North Carolina
Dec 9, 2025 at 4:34 PM#13

Thanks for sharing this, Dr.GastroMayo. A few questions about your Retatrutide and experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Retatrutide and?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

10 4PharmD_Rodriguez, julia.endo, JessicaM_2024 and 7 others
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Dr.GastroMayo
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Mayo Clinic, MN
Dec 9, 2025 at 4:51 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Retatrutide and fatty.

To answer PharmHunterJen: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Dec 9, 2025 at 9:51 PM
49 11MikeFit_NJ, InsuranceTom, WendyG_ATL and 46 others
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FDA_TrackerJim
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Rockville, MD
Dec 9, 2025 at 5:08 PM#15

Relevant to Retatrutide and fatty liver 6 — here is my latest bloodwork comparison:

Key improvements: A1C 7.2% → 5.3%, triglycerides 207 → 107 mg/dL, hsCRP 6.0 → 1.3 mg/L. All on tirzepatide for 11 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

1 1jason_paloalto
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