OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Glucagon receptor agonism.
To answer PedsEndoPhilly: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
Relevant to Glucagon receptor agonism and — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
100%. My provider said the same thing about Glucagon receptor.
Slightly tangential to Glucagon receptor agonism but ChrisMacros reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
mike_mod said:Thank you all for the thoughtful replies on Glucagon receptor agonism
This is exactly right. mike_mod articulated what I have been trying to explain to my doctor for months. The Glucagon receptor agonism aspect is the most important factor.