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ForumsMASH / Liver DiseaseDe novo lipogenesis reduction on GLP-1 — mechanistic hepatology Page 4

De novo lipogenesis reduction on GLP-1 — mechanistic hepatology

MASHdoc_SA Mon, Jun 1, 2026 at 1:48 AM 17 replies 523 viewsPage 4 of 4
gary_naperville
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245
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Oct 2024
Naperville, IL
Jun 1, 2026 at 7:28 AM#16

Congrats LarryQC_SD!! Keep going — you're doing incredible. 🎉 👏

17 24SleepFixSam, PurityPaulOR, MaxMetOK and 14 others
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mia_MS2
New Member
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23
Jun 2026
Ann Arbor, MI
Jun 1, 2026 at 7:45 AM#17

Exactly this. My pharmacist said the same thing about De novo lipogenesis.

25 2FDA_TrackerJim, ricardo_MIA, BrianDallas92 and 22 others
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amsterdam_pete
Senior Member
1,567
6,789
Feb 2024
Netherlands
Jun 1, 2026 at 8:02 AM#18
NurseLeah_Nash said:
Especially the point about "Thank you all for the thoughtful replies

This is exactly right. NurseLeah_Nash articulated what I have been trying to explain to my friends for months. The De novo lipogenesis aspect is what made the difference for me.

14 5CanadaChris, ZaraB_AL, JakeSmashed95 and 11 others
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MounjBrad
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278
890
Oct 2024
Kentucky
Jun 1, 2026 at 8:19 AM#19

Same experience here with De novo lipogenesis. amsterdam_pete described it perfectly.

7 7pam_columbus, nick_SD_fit, ben_calgary and 4 others
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RunnerRach
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467
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Aug 2024
Boston, MA
Jun 1, 2026 at 8:36 AM#20

Slightly tangential to De novo lipogenesis but mia_MS2 reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

9 10tyler_CSCS, VanRx_Mike, steve_okc and 6 others
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