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ForumsMASH / Liver DiseaseMy liver enzyme journey — ALT from 98 to 19 on semaglutide Page 4

My liver enzyme journey — ALT from 98 to 19 on semaglutide

DerekSJ_a1c Wed, May 27, 2026 at 9:10 AM 29 replies 552 viewsPage 4 of 6
DerekSJ_a1c
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Aug 2024
San Jose, CA
May 27, 2026 at 2:50 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on My liver enzyme journey .

To answer wanda_boise: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

6 20adam_van, Dr.SurgeonPGH, rachel_ABQ and 3 others
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Dr.PeteFamMed
Senior Member
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9,234
Jan 2024
Minneapolis, MN
May 27, 2026 at 3:07 PM#17

Relevant to My liver enzyme journey ALT — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 211 → 111 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

22 11tommy_boulder, hyun_seoul, jim_asheville and 19 others
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PeptideSynthNJ
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Aug 2024
Princeton, NJ
May 27, 2026 at 3:24 PM#18

Yep. My endo said the same thing about My liver enzyme.

19 8BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 16 others
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Dr.AddMedPHL
Senior Member
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6,234
Mar 2024
Philadelphia, PA
May 27, 2026 at 3:41 PM#19

Slightly tangential to My liver enzyme journey but BiostatsBrad reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

29 21TomFromTexas, mike.trainer_LA, sarah_nash92 and 26 others
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FranDenver
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Oct 2024
Denver, CO
May 27, 2026 at 3:58 PM#20
DerekSJ_a1c said:
Thank you all for the thoughtful replies on My liver enzyme journey

This is exactly right. DerekSJ_a1c articulated what I have been trying to explain to my friends for months. The My liver enzyme journey aspect is what made the difference for me.

13 19GenomicsKate, Dr.ObesityMed, HealthEcon_DC and 10 others
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