+1 to amsterdam_pete. Especially the point about "Re: Marathon PR after 80 lbs — the subgr..." — I have seen the same in my own experience with Marathon PR after 80 lbs.
Want to share my personal experience related to Marathon PR after 80 lbs since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 264 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 6 months later: I am down 59 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Marathon PR after 80 aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
traveltech_sara — that is really helpful context on Marathon PR after 80 lbs. Follow-up question: did you change anything about your diet at the same time?
I am in a similar situation (month 2) and trying to set realistic expectations.
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Browse GL BiochemTo answer Dr.EM_Chicago's question specifically:
From a clinical standpoint, Marathon PR after 80 lbs is well-supported by the literature.
The short answer: follow the standard titration protocol and reassess at 4-6 weeks.
The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.
Saving this for reference. Top-tier content.