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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHow to read a Certificate of Analysis — complete guide Page 5

How to read a Certificate of Analysis — complete guide

COA_Karl Mon, Feb 26, 2024 at 4:00 PM 53 replies 16,488 viewsPage 5 of 11
SandraNC_45
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Feb 26, 2024 at 11:05 PM#21

cory_ATX — that is really helpful context on How to read a Certificate. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

Last edited: Feb 27, 2024 at 4:05 AM
35 15FranDenver, Dr.BariatricHTX, LindaRN_retired and 32 others
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LindaRN_retired
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Feb 26, 2024 at 11:22 PM#22

To answer SleepDoc_PDX's question specifically:

From a clinical standpoint, How to read a Certificate of is well-supported by the literature.

The short answer: follow the standard titration protocol and reassess at 4-6 weeks.

The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.

46 3Dr.GutHealth, amsterdam_pete, LondonLisa and 43 others
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lori_vegas
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Feb 26, 2024 at 11:39 PM#23

SandraNC_45 — wow. This community is amazing.

50 20oliver_london, tane_welly, Dr.PathRoch and 47 others
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Dr.RaviCardio
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Feb 26, 2024 at 11:56 PM#24

Adding my data to this How to read a Certificate discussion:

MetricBaselineMonth 3Month 8
Weight262 lbs232 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

Last edited: Feb 27, 2024 at 12:56 AM
38 15hans_munich, jason_sac26, chris_chi24 and 35 others
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SarahChen_PharmD
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Feb 27, 2024 at 12:13 AM#25

Slightly tangential to How to read a Certificate but SandraNC_45 reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

3 2robert_kc, dan_philly, MeganSA_TX
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