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ForumsCOA & Analytical TestingHPLC vs UPLC for peptide purity — method comparison study Page 3

HPLC vs UPLC for peptide purity — method comparison study

kate.chem Mon, Jun 8, 2026 at 11:18 AM 18 replies 450 viewsPage 3 of 4
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Jun 8, 2026 at 3:33 PM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

24 6PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 21 others
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Dr.SportsMedIN
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Jun 8, 2026 at 3:50 PM#12

Slightly tangential to HPLC vs UPLC for peptide but pete_manc_UK reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Jun 8, 2026 at 8:50 PM
7 3lisa_labSD, adam_van, Dr.SurgeonPGH and 4 others
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BrianDallas92
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Jun 8, 2026 at 4:07 PM#13
LeilaHI said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. LeilaHI articulated what I have been trying to explain to my friends for months. The HPLC vs UPLC for peptide aspect is what made the difference for me.

21 2andrew_nyc, Dr.EndoEP, GraceAZ_72 and 18 others
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Dr.SurgeonPGH
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Jun 8, 2026 at 4:24 PM#14

Saving this for reference. Quality thread.

5 17RickReta_CO, PharmHunterJen, TomTeleRx and 2 others
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SleepDoc_PDX
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Jun 8, 2026 at 4:41 PM#15

Adding my data to this HPLC vs UPLC for peptide discussion:

MetricBaselineMonth 3Month 6
Weight272 lbs242 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.00.6

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

18 19mel_PDX, Dr.AddMedPHL, newstart_MO and 15 others
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