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ForumsSide Effects & ManagementInjection site reactions — my results so far Page 2

Injection site reactions — my results so far

VendorMark Tue, Feb 24, 2026 at 4:14 AM 30 replies 1,403 viewsPage 2 of 6
Dr.PeteFamMed
Senior Member
2,012
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Jan 2024
Minneapolis, MN
Feb 24, 2026 at 7:04 AM#6

UPDATE — tried warming + icing:

Took the pen out 30 min early, iced the spot for 3 min before, injected slowly (held 10 seconds), iced for 5 min after, didn't rub.

Result: still got a small lump but it's maybe 60% smaller than usual and the redness cleared by day 2 instead of day 5. HUGE improvement!! Going to keep doing this. Thank you all so much 🙏

40 8hyun_seoul, jim_asheville, matt_MKE and 37 others
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hannah_MT
New Member
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89
Feb 2026
Bozeman, MT
Feb 24, 2026 at 7:21 AM#7

Glad that helped! The warming is probably the single biggest factor. That medication is viscous when cold and creates more tissue disruption on injection. Most patients who implement the warming step alone see significant improvement.

32 1MounjBrad, nick_newbie, DadBodDave and 29 others
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MarkLI_maint
Member
534
2,345
Jun 2024
Long Island, NY
Feb 24, 2026 at 7:38 AM#8

Great improvement Laura! If the smaller lumps still bother you, a thin layer of OTC hydrocortisone cream on the injection site after the post-injection icing can help with the residual inflammation. Just don't apply it BEFORE injection — you want the area clean and dry pre-injection. 👩‍⚕️

33 23HPLC_Greg, LibrarianMeg, bri_stats and 30 others
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