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ForumsCOA & Analytical TestingLC-MS/MS vs HPLC for peptide analysis — which is more reliable? Page 4

LC-MS/MS vs HPLC for peptide analysis — which is more reliable?

HPLC_Greg Wed, Jun 3, 2026 at 8:25 AM 19 replies 492 viewsPage 4 of 4
amy_econ_NJ
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Princeton, NJ
Jun 3, 2026 at 2:05 PM#16

Congrats LipidDoc_ATL!! Keep going — you're doing incredible. 🎉 👏

27 23Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 24 others
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SandraNC_45
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Sep 2024
Charlotte, NC
Jun 3, 2026 at 2:22 PM#17

Reading this thread on LC-MS/MS vs HPLC for hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about LC-MS/MS vs HPLC for — take the leap. It was the best health decision I have ever made. ❤️

34 6james_edin, FranDenver, Dr.BariatricHTX and 31 others
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pam_stl
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Oct 2024
St. Louis, MO
Jun 3, 2026 at 2:39 PM#18

traveltech_sara — that is really helpful context on LC-MS/MS vs HPLC for. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jun 3, 2026 at 7:39 PM
5 20PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 2 others
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AmyNC_wife
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Jun 3, 2026 at 2:56 PM#19

Reading this thread on LC-MS/MS vs HPLC for hits close to home. Dad of 2 checking in — I started at 289 lbs and felt like I would tried everything.

15 months on tirz and I am a different person. Not just the 64 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about LC-MS/MS vs HPLC for — take the leap. It was the best health decision I have ever made. ❤️

1 24Dr.NateNeph
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CanadaChris
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Nov 2024
Toronto, CA
Jun 3, 2026 at 3:13 PM#20

AmyNC_wife — that is really helpful context on LC-MS/MS vs HPLC for. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Jun 3, 2026 at 9:13 PM
21 4lori_vegas, Dr.PulmRoch, maya_sedona and 18 others
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