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ForumsSide Effects & ManagementDiarrhea vs constipation on GLP-1 — anyone have experience? Page 5

Diarrhea vs constipation on GLP-1 — anyone have experience?

HPLC_Greg Sun, Jan 4, 2026 at 3:28 AM 21 replies 1,190 viewsPage 5 of 5
carl_compliance
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Jan 4, 2026 at 10:33 AM#21

Dr.GutHealth — that is really helpful context on Diarrhea vs constipation. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

Last edited: Jan 4, 2026 at 1:33 PM
2 11labquiet_amy, emily_PDX
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PharmacoVig_BOS
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Jan 4, 2026 at 10:50 AM#22

To answer adam_van's question specifically:

From a clinical standpoint, Diarrhea vs constipation on is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

28 12Dr.GutHealth, amsterdam_pete, LondonLisa and 25 others
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LondonLisa
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Jan 4, 2026 at 11:07 AM#23

Thank you carl_compliance! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Jan 4, 2026 at 1:07 PM
10 16RetaRick_CA, JenPlateau, SallyK_inj and 7 others
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LabKate
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Jan 4, 2026 at 11:24 AM#24

Relevant to Diarrhea vs constipation on — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: Jan 4, 2026 at 2:24 PM
31 21emily_PDX, Dr.SleepRoch, laura_annarbor and 28 others
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LibrarianMeg
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Jan 4, 2026 at 11:41 AM#25

Slightly tangential to Diarrhea vs constipation but carl_compliance reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

27 7TomFromTexas, mike.trainer_LA, sarah_nash92 and 24 others
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