Not losing weight but my clothes fit different?? Explain

KevinCompounds

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Feb 23, 2026 at 10:21 PM#6

Dr.SurgeonPGH said:
Explain — in my experience this comes down to a few key factors

Gonna push back on this one. Not losing weight but my clothes is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Last edited: Feb 24, 2026 at 12:21 AM

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LabKate

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Feb 23, 2026 at 10:38 PM#7

Adding my data to this Not losing weight but my discussion:

Metric	Baseline	Month 5	Month 8
Weight	266 lbs	231 lbs	221 lbs
A1C	7.0%	6.0%	5.4%
hsCRP	5.0	4.0	0.8

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

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CanadaChris

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Feb 23, 2026 at 10:55 PM#8

EndoResFellow — wow. I've been looking for this exact info for weeks.

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Dr.CardioMD

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Feb 23, 2026 at 11:12 PM#9

Slightly tangential to Not losing weight but my but KristenIndy reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Feb 24, 2026 at 5:12 AM

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