🍪 The GLP Lounge uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsDown 50 lbs and nobody at work has said a WORD

Down 50 lbs and nobody at work has said a WORD

gary_naperville Sat, Feb 7, 2026 at 10:08 PM 7 replies 859 viewsPage 1 of 2
gary_naperville
Member
245
1,123
Oct 2024
Naperville, IL
Feb 7, 2026 at 11:33 PM#1

Hi all, brand new here. My NP just prescribed semaglutide and I have a question about down 50 lbs and nobody at.

Sorry if this has been asked before — I did try searching but the amount of information here is overwhelming (in a good way). I am on day 3 and everything is new to me.

Any guidance appreciated. You all seem really knowledgeable and I am glad I found this community.

23 1SleepFixSam, PurityPaulOR, MaxMetOK and 20 others
Reply Quote Save Share Report
Dr.ObesityLA
VIP Member
3,567
19,876
Dec 2023
Los Angeles, CA
Feb 7, 2026 at 11:50 PM#2

gary_naperville's experience with Down 50 lbs and nobody at resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 48 lbs in 13 months.

One thing I would add that gary_naperville did not mention: the relationship with food fundamentally changed.

Last edited: Feb 8, 2026 at 12:50 AM
12 1KarenAZ_mom, zoe_NC, Dr.ObesityLA and 9 others
Reply Quote Save Share Report
mike_nyc
VIP Member
5,678
21,345
Nov 2023
New York
Online
Feb 8, 2026 at 12:07 AM#3

Thanks for sharing this, gary_naperville. A few questions about your Down 50 lbs and experience:

  1. What dose are you currently on?
  2. How long before you noticed significant changes?
  3. Did your doctor have any specific recommendations about Down 50 lbs and?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

46 6Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 43 others
Reply Quote Save Share Report
gary_naperville
Member
245
1,123
Oct 2024
Naperville, IL
Feb 8, 2026 at 12:24 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Down 50 lbs and nobody at.

To answer mike_nyc: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

20 16PharmHunterJen, TomTeleRx, DoseLogDan and 17 others
Reply Quote Save Share Report
quinn_sf
Member
489
2,123
Jun 2024
San Francisco, CA
Feb 8, 2026 at 12:41 AM#5

Relevant to Down 50 lbs and nobody at work — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 201 → 101 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

26 10Dr.EndoEP, GraceAZ_72, carl_compliance and 23 others
Reply Quote Save Share Report

Similar Threads

100 lbs lost in 14 months — comprehensive DEXA and lab data16 replies
12-month metabolic panel comparison — before and after GLP-122 replies
A1C from 9.2 to 5.4 in 8 months — my diabetes reversal journey16 replies
6-month body recomposition — DEXA, labs, progress photos22 replies
1-year semaglutide anniversary — honest review with all data16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register