Oct 20, 2025 at 4:54 AM#6
Subscribing to this thread. When to stop GLP-1 need is exactly what I've been researching. 🙏
Last edited: Oct 20, 2025 at 10:54 AM
38 14sarah_nash92, FitDadDave, RunnerRach and 35 others
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Oct 20, 2025 at 5:11 AM#7
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on When to stop GLP-1 need.
To answer sarah.morrison: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
27 15HealthEcon_DC, PedsEndoPhilly, SleepDoc_PDX and 24 others
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Oct 20, 2025 at 5:28 AM#8
Relevant to When to stop GLP-1 need — here is my latest bloodwork comparison:
Key improvements: A1C 7.6% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.
The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.
5 18TomFromTexas, mike.trainer_LA, sarah_nash92 and 2 others
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Oct 20, 2025 at 5:45 AM#9
pam_stl said:Thank you all for the thoughtful replies on When to stop GLP-1 need
This is exactly right. pam_stl articulated what I have been trying to explain to my friends for months. The When to stop GLP-1 need aspect is what made the difference for me.
23 1ricardo_MIA, BrianDallas92, labquiet_amy and 20 others
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Oct 20, 2025 at 6:02 AM#10
Slightly tangential to When to stop GLP-1 need but AttorneyGrant reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
21 3BethLabQueen, ChrisMacros, KetoKyle and 18 others
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