Just wanted to say — for anyone reading this Day 3 on sema and I thread who is feeling discouraged: it gets better. The first 6 weeks are the hardest. Hang in there. 💪
Slightly tangential to Day 3 on sema and I feel but mike_mod reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
Exactly this. My pharmacist said the same thing about Day 3 on sema and I.
Want to share my personal experience related to Day 3 on sema and I feel like since I think it might help others in a similar situation.
I started my GLP-1 journey in March 2025 at 247 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.
Now, 10 months later: I am down 67 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The Day 3 on sema and I aspect specifically was something that made a big difference in my journey.
This forum was my go-to resource throughout.
Clinical perspective on Day 3 on sema and I feel like death:
I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.
For this specific question, I would recommend: getting comprehensive baseline labs first.